DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends by using 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal buildings of DNA ligases certain to nucleotide and nucleic acid substrates have illuminated https://mattt234ifx0.blogpixi.com/profile