There is a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lessen afferent discomfort transmission and make analgesia. As a result, medicines like clonidine that goal alpha-2 receptors can influence the transmission of pain. Applies to clonidine: oral pill, https://shulamithe135bts0.blogsvirals.com/profile