BackgroundColorectal cancer (CRC) is the third most prevalent malignancy and the one of most lethal cancer. Metastatic CRC (mCRC) is the third most common cause of cancer deaths worldwide. DNA damage response (DDR) genes are closely associated with the tumorigenesis and development of CRC. https://www.jmannino.com/super-save-NFL-Chicago-Bears-Blast-iPhone-14-Plus-Skin-p41373-big-savings/